Journal: Cardiology Clinics

Article Title: Use and Prognostic Implications of Cardiac Troponin in COVID-19

doi: 10.1016/j.ccl.2022.03.005

Figure Lengend Snippet: Frequency of myocardial injury based on hs-cTn concentrations above the 99th percentile URL or above specified thresholds

Article Snippet: Garcia de Guadiana-Romualdo et al, 2021 , Spain, multicenter , 1280 ED COVID-19 patients , Hs-cTnT cTnI Siemens Atellica cTnI Siemens Advia Centaur cTn I Siemens Dimension EXL cTnI Abbott Architect cTn I Beckman DxI 800/Access , >99th URL , 26.9% w/o sex-specific cutoffs 30% with sex-specific cutoffs.

Techniques: Troponin Assay

Journal: Journal of the American College of Cardiology

Article Title: Cardiac Troponin for Assessment of Myocardial Injury in COVID-19

doi: 10.1016/j.jacc.2020.06.068

Figure Lengend Snippet: Summary of Studies Addressing Cardiac Troponin and/or Myocardial Injury in Patients With COVID-19

Article Snippet: Shi et al. ( ) , Renmin Hospital of Wuhan University, Wuhan, China , 416 consecutive patients admitted to hospital with laboratory-confirmed COVID-19. Cases without cardiac biomarkers, including values of cTnI and CK-MB were excluded , With cardiac injury: HTN: 59.8% CHD: 29.3% CHF: 14.6% Without injury: HTN: 23.4% CHD: 6.0% CHF: 1.5% , cTn assay details NR cTnI (Siemens ADVIA Centaur); lowest measurable value <0.006 ng/ml; >0.04 ng/ml was considered indicative of cardiac injury and >0.78 ng/ml suggesting myocardial infarction possible Cardiac injury was defined as blood levels of cardiac biomarkers (hs-cTnI) above the 99th percentile upper reference limit, regardless of new abnormalities in electrocardiography and echocardiography , Cardiac injury: 82 of 416 (19.7%) cTnI (median) All: <0.006 (IQR: <0.006–0.02) Cardiac injury: 0.19 (IQR: 0.08–1.12) Without injury: <0.006 (IQR: <0.006–0.009) , Death Cardiac injury, 51.2% Without injury, 4.5% Mortality rate increased in association with the magnitude of the reference value of cTnI Cox proportional hazard regression model showed significant higher risk of death in patients with cardiac injury than in those without, either during time from symptom onset (HR: 4.2; 95% CI: 1.92–9.49) or time from admission to study endpoint (HR: 3.41; 95% CI: 1.62–7.16) , Chest pain: Cardiac injury, 13.4% Without injury, 0.9%.

Techniques: Troponin Assay, Isolation, Infection, Blocking Assay, Biomarker Discovery, Virus, Concentration Assay

Journal: Circulation

Article Title: Optimal Cutoff Levels of More Sensitive Cardiac Troponin Assays for the Early Diagnosis of Myocardial Infarction in Patients With Renal Dysfunction

doi: 10.1161/CIRCULATIONAHA.114.014245

Figure Lengend Snippet: Baseline levels of more sensitive cardiac troponin (cTn) assays at presentation in patients with final diagnosis other than acute myocardial infarction. cTn levels are displayed as multiples of the 99th percentile. Boxes represent interquartile ranges; whiskers display ranges (without outliers further than 1.5 interquartile ranges). Left , In patients with renal dysfunction. Right , In patients with normal renal function. hs indicates high-sensitivity; and s, sensitive.

Article Snippet: The optimal cutoff levels to separate AMI from other conditions underlying acute chest pain in the ED determined by the receiver-operator characteristic curve analysis in patients with renal dysfunction were close to the 99th percentile for the 3 s-cTn assays (1.0 times the 99th percentile for Abbott-Architect s-cTnI, 1.2 times the 99th percentile for Siemens Ultra s-cTnI, and 0.9 times the 99th percentile for Beckman-Coulter Accu s-cTnI) and substantially higher for most hs-cTn assays (2.1 times the 99th percentile for Roche hs-cTnT, 1.1 times the 99th percentile for Abbott-Architect hs-cTnI, 3.6 times the 99th percentile for Siemens hs-cTnI, and 2.8 times the 99th percentile for Beckman-Coulter hs-cTnI).

Techniques: Biomarker Discovery

Journal: Circulation

Article Title: Optimal Cutoff Levels of More Sensitive Cardiac Troponin Assays for the Early Diagnosis of Myocardial Infarction in Patients With Renal Dysfunction

doi: 10.1161/CIRCULATIONAHA.114.014245

Figure Lengend Snippet: Distribution of final diagnoses in patients with renal dysfunction and cardiac troponin (cTn) levels above the 99th percentile at presentation. hs Indicates high-sensitivity; and s, sensitive. *Coronary artery disease.

Article Snippet: The optimal cutoff levels to separate AMI from other conditions underlying acute chest pain in the ED determined by the receiver-operator characteristic curve analysis in patients with renal dysfunction were close to the 99th percentile for the 3 s-cTn assays (1.0 times the 99th percentile for Abbott-Architect s-cTnI, 1.2 times the 99th percentile for Siemens Ultra s-cTnI, and 0.9 times the 99th percentile for Beckman-Coulter Accu s-cTnI) and substantially higher for most hs-cTn assays (2.1 times the 99th percentile for Roche hs-cTnT, 1.1 times the 99th percentile for Abbott-Architect hs-cTnI, 3.6 times the 99th percentile for Siemens hs-cTnI, and 2.8 times the 99th percentile for Beckman-Coulter hs-cTnI).

Techniques:

Journal: Circulation

Article Title: Optimal Cutoff Levels of More Sensitive Cardiac Troponin Assays for the Early Diagnosis of Myocardial Infarction in Patients With Renal Dysfunction

doi: 10.1161/CIRCULATIONAHA.114.014245

Figure Lengend Snippet: Diagnostic performance of cardiac troponin (cTn) at presentation in renal dysfunction. Receiver-operating characteristic (ROC) curves are describing the diagnostic performance of the 3 sensitive (s; green) and 4 high-sensitivity (hs; red) cTn assays at presentation for the diagnosis of acute myocardial infarction in patients with renal dysfunction. The figure containing multiple curves (upper left corner) is based on the subset of patients in whom data for all 7 assays are available. The figures for the individual assays are based on all patients with available data for the respective assays to maximize precision for the determination of the respective predefined cutoff levels, which are marked as follows: 1=99th percentile, 2=optimal cutoff derived from the ROC curve, 3=sensitivity ≥90%, 4=sensitivity ≥95%, 5=specificity ≥80%, and 6=specificity ≥90%.

Article Snippet: The optimal cutoff levels to separate AMI from other conditions underlying acute chest pain in the ED determined by the receiver-operator characteristic curve analysis in patients with renal dysfunction were close to the 99th percentile for the 3 s-cTn assays (1.0 times the 99th percentile for Abbott-Architect s-cTnI, 1.2 times the 99th percentile for Siemens Ultra s-cTnI, and 0.9 times the 99th percentile for Beckman-Coulter Accu s-cTnI) and substantially higher for most hs-cTn assays (2.1 times the 99th percentile for Roche hs-cTnT, 1.1 times the 99th percentile for Abbott-Architect hs-cTnI, 3.6 times the 99th percentile for Siemens hs-cTnI, and 2.8 times the 99th percentile for Beckman-Coulter hs-cTnI).

Techniques: Diagnostic Assay, Biomarker Discovery, Derivative Assay